Bacteriophage therapy is a promising alternative to antibiotic therapy . Sepsis is a syndromic response to illness, according to scientists .
Varanasi: Scientists from the Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, have argued that bacterial viruses or bacteriophages isolated from sewer or river water can save human life by refining them in labs and using them to destroy the resistant disease-causing bacteria that reside in contaminated waters, stressing the value of bacteriophage therapy.They also said that typhoid can be eradicated from the planet by the use of bacteriophage, which are the living organisms that live in the world.They only affect bacteria and are harmless to people, animals, and plants.Phages or bacteriophages are the natural enemies of bacteria that are created by bacteria.Sepsis is a syndromic response to illness, according to him.It could be the last common path to death from a variety of infectious diseases in the world.According to an estimate, 20 percent of all global deaths are due to septicaemia, and about 85 percent of sepsis cases and related deaths occur in developing countries.He said that specific unresolved problems, such as the optimization of safe dosages (quantity and frequency), administration methods, and the development of bacteriophage resistance during therapy must be worked out thoroughly before clinical trials are conducted. The bacteriophages kill the bacteria by damaging the cell wall, so their use may have similar consequences if the dosage isn't modified.In the preclinical trial, we attempted to establish the appropriate dosage for the various stages of septicaemia.Phage therapy has been shown to be safe against the Klebsiella pneumoniae septicaemia mice model and is a promising alternative to antibiotic therapy, he said.He said, Our research shows that a single dose of phage mixture shields the mice from fatal consequences at any stage of septicaemia. In addition, repeated doses are needed to remove the bacteria from the peripheral blood.In the Indian journal of Medical Research and Annals of the National Academy of Medical Sciences, we have already published about the effectiveness of bacteriophages in a sepsis model caused by Staphylococcus aureus.We are examining two new organisms of the ESKAPE family, Enterobacter and Enterococcus spp.Prof. Nath said that the findings obtained in this study have far-reaching implications in clinical practice in the coming years.